26.[20220915]Acute graft thrombosis in patients who underwent renaltra…
페이지 정보
작성자 신호식 작성일23-02-03 13:25 조회453회 댓글0건관련링크
-
https://youtu.be/j7fFizv8Ma0
451회 연결
https://youtu.be/j7fFizv8Ma0
본문
첨부한 자료(유튜브 클립, 참고문헌 등)를 학문적 목적으로만 사용해 주시길 부탁드립니다
Review Am J Clin Exp Urol
. 2022 Jun 15;10(3):129-141. eCollection 2022.
Acute graft thrombosis in patients who underwent renal transplant and received anticoagulant or antiplatelet agents. A systematic review and meta-analysis
Rodrigo Guerra 1, Paulo Roberto Kawano 1, Marcelo Petean Amaro 2, Hamilto Akihissa Yamamoto 1, Fernando Ferreira Gomes Filho 1, João Luiz Amaro 1, Regina Paolucci El Dib 1, Herney Andres Garcia-Perdomo 3, Leonardo Oliveira Reis 2
Affiliations expand
PMID: 35874286 PMCID: PMC9301061
Free PMC article
Abstract
Objectives: Thrombosis is a major cause of early allograft loss in renal transplantation. Herein, we assessed the frequency of acute graft thrombosis in patients who underwent renal transplant and received anticoagulant or antiplatelet agents.
Methods: We performed a systematic review of all available case series studies of anticoagulant and/or antiplatelet prophylaxis of thrombosis in renal transplantation. The data were pooled in a proportional meta-analysis.
Results: Twenty-one case series were identified from 7,160 retrieved titles. A total of 3,246 patients were analyzed (1,718 treated with antiplatelet and/or anticoagulant agents and 1,528 non-treated control subjects). Allograft thrombosis occurred in 7.24% (95% CI 3.45 to 12.27%) of the patients receiving no intervention compared with 3.38% (95% CI 1.45 to 6.1%), 1.2% (95% CI 0.6 to 2.1%) and 0.47% (95% CI 0.001 to 1.79%) of the patients in the anticoagulant, aspirin, and aspirin + anticoagulant groups, respectively. The bleeding complication rate for anticoagulants was significantly higher than in the other groups.
Conclusions: Our data suggests that anticoagulants, and aspirin, either alone or in association with an anticoagulant, seem to have a low frequency of acute allograft thrombosis after kidney transplantation. Higher hemorrhagic complication rates might occur when anticoagulants are used.
Review Am J Clin Exp Urol
. 2022 Jun 15;10(3):129-141. eCollection 2022.
Acute graft thrombosis in patients who underwent renal transplant and received anticoagulant or antiplatelet agents. A systematic review and meta-analysis
Rodrigo Guerra 1, Paulo Roberto Kawano 1, Marcelo Petean Amaro 2, Hamilto Akihissa Yamamoto 1, Fernando Ferreira Gomes Filho 1, João Luiz Amaro 1, Regina Paolucci El Dib 1, Herney Andres Garcia-Perdomo 3, Leonardo Oliveira Reis 2
Affiliations expand
PMID: 35874286 PMCID: PMC9301061
Free PMC article
Abstract
Objectives: Thrombosis is a major cause of early allograft loss in renal transplantation. Herein, we assessed the frequency of acute graft thrombosis in patients who underwent renal transplant and received anticoagulant or antiplatelet agents.
Methods: We performed a systematic review of all available case series studies of anticoagulant and/or antiplatelet prophylaxis of thrombosis in renal transplantation. The data were pooled in a proportional meta-analysis.
Results: Twenty-one case series were identified from 7,160 retrieved titles. A total of 3,246 patients were analyzed (1,718 treated with antiplatelet and/or anticoagulant agents and 1,528 non-treated control subjects). Allograft thrombosis occurred in 7.24% (95% CI 3.45 to 12.27%) of the patients receiving no intervention compared with 3.38% (95% CI 1.45 to 6.1%), 1.2% (95% CI 0.6 to 2.1%) and 0.47% (95% CI 0.001 to 1.79%) of the patients in the anticoagulant, aspirin, and aspirin + anticoagulant groups, respectively. The bleeding complication rate for anticoagulants was significantly higher than in the other groups.
Conclusions: Our data suggests that anticoagulants, and aspirin, either alone or in association with an anticoagulant, seem to have a low frequency of acute allograft thrombosis after kidney transplantation. Higher hemorrhagic complication rates might occur when anticoagulants are used.
