2023-Chimeric antigen receptor T reg therapy in transplantation.

In the quest formore precise and effective organ transplantation therapies, chimeric
antigen receptor (CAR) regulatory T cell (Treg) therapies represent a potential
cutting-edge advance. This review comprehensively analyses CAR Tregs and
how they may address important drawbacks of polyclonal Tregs and conventional
immunosuppressants. We examine a growing body of preclinical findings of CAR
Treg therapy in transplantation, discuss CAR Treg design specifics, and explore
established and attractive new targets in transplantation. In addition, we explore
present impediments where future studies will be necessary to determine the
efficacy of CAR Tregs in reshaping alloimmune responses and transplant microenvironments
to reduce reliance on chemical immunosuppressants. Overall,
ongoing studies and trials are crucial for understanding the full scope of CAR
Treg therapy in transplantation.