155.[20230122]Paradigm shift in lifestyle modification for solitary kidney after donor nephrectomy > 1분 논문읽기

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KOSIN UNIVERSITY COLLEGE OF MEDICINE

155.[20230122]Paradigm shift in lifestyle modification for solitary ki…

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작성자 신호식 작성일23-02-03 14:19 조회502회 댓글0건

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Review Curr Opin Nephrol Hypertens
. 2023 Jan 1;32(1):67-75. doi: 10.1097/MNH.0000000000000853. Epub 2022 Nov 7.
Paradigm shift in lifestyle modification for solitary kidney after donor nephrectomy
Ekamol Tantisattamo 1 2 3, Kamyar Kalantar-Zadeh 1 2 4
Affiliations expand
PMID: 36444664 DOI: 10.1097/MNH.0000000000000853
Abstract
Purpose of review: Living donor kidney transplantation potentially leads to long-term complications including chronic kidney disease, end-stage kidney disease, elevated blood pressure, and pregnancy-associated hypertension. Given living donors generally do not have underlying medical conditions, lifestyle modifications, particularly dietary interventions may prevent those complications and improve their health outcomes.

Recent findings: Glomerular hyperfiltration occurs as physiologic adaptation during an initial postdonor nephrectomy period. In the long-term, these adaptations may become pathologic consequences resulting from hyperfiltration-mediated kidney injury and ultimately secondary focal segmental glomerulosclerosis in the solitary kidney. Dietary interventions to slow a decline in kidney function include low protein intake of <0.8 g/kg/day and low sodium consumption of 2-4 g/day as well as certain health dietary patterns. There is no evidence regarding the quantity and quality of protein that can be recommended for living kidney donors and the same for sodium. Plant Dominant (PLADO) diets, Dietary Approaches to Stop Hypertension (DASH), Mediterranean, and vegetarian diets may be favorable for living kidney donors with solitary kidney but the evidence is still lacking.

Summary: Although dietary interventions may provide benefits and kidney health for living kidney donors, further studies including clinical trials are required to incorporate them into clinical practice guidelines.



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