134.[20230101]Frailty in kidney transplantation
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Review Clin Kidney J
. 2022 May 24;15(11):2020-2026. doi: 10.1093/ckj/sfac149. eCollection 2022 Nov.
Frailty in kidney transplantation: a review on its evaluation, variation and long-term impact
Carlo Alfieri 1 2, Silvia Malvica 1, Matteo Cesari 2 3, Simone Vettoretti 1, Matteo Benedetti 1, Elisa Cicero 1, Roberta Miglio 1, Lara Caldiroli 1, Alessandro Perna 4, Angela Cervesato 4, Giuseppe Castellano 1 2
Affiliations expand
PMID: 36325001 PMCID: PMC9613431 DOI: 10.1093/ckj/sfac149
Free PMC article
Abstract
The problem of frailty in kidney transplantation is an increasingly discussed topic in the transplant field, partially also generated by the multiple comorbidities by which these patients are affected. The criteria currently used to establish the presence and degree of frailty can be rapidly assessed in clinical practice, even in patients with chronic kidney disease (CKD). The main objectives of this work are: (i) to describe the method of evaluation and the impact that frailty has in patients affected by CKD, (ii) to explore how frailty should be studied in the pre-transplant evaluation, (iii) how frailty changes after a transplant and (iv) the impact frailty has over the long term on the survival of renal transplant patients.
Keywords: chronic kidney disease; frailty; graft survival; renal transplantation.
Review Clin Kidney J
. 2022 May 24;15(11):2020-2026. doi: 10.1093/ckj/sfac149. eCollection 2022 Nov.
Frailty in kidney transplantation: a review on its evaluation, variation and long-term impact
Carlo Alfieri 1 2, Silvia Malvica 1, Matteo Cesari 2 3, Simone Vettoretti 1, Matteo Benedetti 1, Elisa Cicero 1, Roberta Miglio 1, Lara Caldiroli 1, Alessandro Perna 4, Angela Cervesato 4, Giuseppe Castellano 1 2
Affiliations expand
PMID: 36325001 PMCID: PMC9613431 DOI: 10.1093/ckj/sfac149
Free PMC article
Abstract
The problem of frailty in kidney transplantation is an increasingly discussed topic in the transplant field, partially also generated by the multiple comorbidities by which these patients are affected. The criteria currently used to establish the presence and degree of frailty can be rapidly assessed in clinical practice, even in patients with chronic kidney disease (CKD). The main objectives of this work are: (i) to describe the method of evaluation and the impact that frailty has in patients affected by CKD, (ii) to explore how frailty should be studied in the pre-transplant evaluation, (iii) how frailty changes after a transplant and (iv) the impact frailty has over the long term on the survival of renal transplant patients.
Keywords: chronic kidney disease; frailty; graft survival; renal transplantation.