147.[20230114]Changes in Glomerular Volume, Sclerosis, and Ischemia at 5 Years after KT > 1분 논문읽기

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KOSIN UNIVERSITY COLLEGE OF MEDICINE

147.[20230114]Changes in Glomerular Volume, Sclerosis, and Ischemia at…

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작성자 신호식 작성일23-02-03 14:16 조회517회 댓글0건

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J Am Soc Nephrol
. 2022 Nov 17;ASN.2022040418. doi: 10.1681/ASN.2022040418. Online ahead of print.
Changes in Glomerular Volume, Sclerosis, and Ischemia at 5 Years after Kidney Transplantation: Incidence and Correlation with Late Graft Failure
Aleksandar Denic 1, Marija Bogojevic 1, Rashmi Subramani 1, Walter D Park 2, Byron H Smith 3, Mariam P Alexander 4, Joseph P Grande 4, Aleksandra Kukla 1, Carrie A Schinstock 1, Andrew J Bentall 1, Andrew D Rule 1, Mark D Stegall 5
Affiliations expand
PMID: 36396330 DOI: 10.1681/ASN.2022040418
Abstract
Background: Histology can provide insight into the biology of renal allograft loss. However, studies are lacking that use quantitative morphometry to simultaneously assess changes in mean glomerular volume and in the percentages of globally sclerosed glomeruli (GSG) and ischemic-appearing glomeruli in surveillance biopsies over time to determine whether such changes are correlated with late graft failure.

Methods: We used digital scans of surveillance biopsies (at implantation and at 1 and 5 years after-transplantation) to morphometrically quantify glomerular volume and the percentages of GSG and ischemic-appearing glomeruli in a cohort of 835 kidney transplants. Cox proportional hazards models assessed the risk of allograft failure with these three glomerular features.

Results: From implantation to 5 years, mean glomerular volume increased by nearly 30% (from 2.8×106 to 3.6×106 µm3), mean percentage of GSG increased from 3.2% to 13.2%, and mean percentage of ischemic-appearing glomeruli increased from 0.8% to 9.5%. Higher percentages of GSG and ischemic-appearing glomeruli at five-year biopsy predicted allograft loss. The three glomerular features at five-year biopsy were related; the percentage of GSG and the percentage of ischemic glomeruli were positively correlated, and both were inversely correlated to glomerular volume. At 5 years, only 5.3% of biopsies had ≥40% ischemic glomeruli, but 45% of these grafts failed (versus 11.6% for <40% ischemic glomeruli). Higher Banff scores were more common with increasing percentages of GSG and ischemia, but at 5 years, only the percentage of ischemic glomeruli added to predictive models adjusted for Banff scores.

Conclusions: Glomerular changes reflect important pathologic processes that predict graft loss. Measuring glomerular changes quantitatively on surveillance biopsies, especially the proportion of ischemic-appearing glomeruli, may enhance the current Banff system and be a useful surrogate end point for clinical intervention trials.

Keywords: allograft failure; global glomerulosclerosis; glomerular volume; incidence; ischemic glomeruli; kidney biopsy; kidney transplantation; morphometry; sclerosis.



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