당뇨,만성콩팥병 환자에서 DPP4억제제와 조절T세포 관련성 원저 출판(장기이식연구소) > 연구소 자료실

본문 바로가기


연구소 자료

KOSIN UNIVERSITY COLLEGE OF MEDICINE

당뇨,만성콩팥병 환자에서 DPP4억제제와 조절T세포 관련성 원저 출판(장기이식연구소)

페이지 정보

작성자 신호식 작성일23-12-09 12:55 조회258회 댓글0건

첨부파일

본문

당뇨,만성콩팥병 환자에서 DPP4억제제와 조절T세포 관련성 원저 

 

제목: The effect of gemigliptin treatment on immune parameters including regulatory T cells in patients with type 2 diabetes and moderate to very severe chronic renal impairment

 

저자: 김양현,이나겸,허수정,김예나,신호식,정연순,임학

 

소속: 고신의대 장기이식연구소, 신장내과

 

초록: It is crucial to understand the impact of DPP-4 inhibitors on the immune system, particularly T cell differentiation, maturation, and proliferation, in patients with type 2 diabetes and CKD. This prospective observational study aimed to investigate the distribution of immune cells (particularly regulatory T cells), following the administration of gemigliptin, a DPP-4 inhibitor, in patients with type 2

diabetes mellitus and chronic kidney disease. We enrolled 28 patients with type 2 diabetes, aged 20 to 69, who had been taking a daily dose of 50mg gemigliptin for <3 months and had chronic kidney disease stages 3, 4, or 5, including that undergoing dialysis. T regulatory cells were defined as CD4 + CD25 high CD127 low/- FoxP3 + phenotype, and flow cytometry was used to examine the distribution of T regulatory cells. In the patient group, blood samples were collected at baseline, as well as at 3 and 6 months after initiating medication. Of the 28 patients, 17 (60.7%) were male and the mean age was 61.82 ± 8.03 years.

Serum Cr ≥ 1.5 mg/dL was 16 (57%), and Cr < 1.5 mg/dL was 12 (43%). The number of CD4(+)/CD25(+) cells did not significantly increase or decrease in baseline, 3 months, and 6 months time changes, and the number of CD127(-/FoxP3(+) cells did not change significantly. Treatment with gemigliptin for 3 and 6 months did not significantly alter the number, percentage, or ratio of circulating Treg cells in patients with type 2 diabetes and CKD. Therefore, the administration of gemigliptin may help maintain regulatory T cells or have no significant impact




(49267) 부산광역시 서구 감천로(장기려로) 262 고신대학교 의과대학 / 사무팀 Tel. 051-990-6406 Fax. 051-241-5458 / 교학관리팀 Tel. 051-990-6600 Fax. 051-241-0145
Copyright © www.kucm.ac.kr All rights reserved.
^